Quantification of photophobia in visual snow syndrome: A case-control study

Ozan E Eren, Ruth Ruscheweyh, Andreas Straube, Christoph J Schankin
First Published December 22, 2019 Brief Report Find in PubMed
https://doi.org/10.1177/0333102419896780

Results

Patients with VSS had an increased L-VISS-score compared to matched controls [(22.2 ± 5.9 vs. 4.4 ± 4.8; ANOVA, factors VSS and comorbid migraine: Main effect for VSS (F = 100.70; p < 0.001), but not for migraine (F < 0.01; p = 1.00) or the interaction (F = 1.93; p = 0.16)]. An L-VISS-score of 14 identified VSS with a sensitivity and specificity of 95% (Receiver Operating Characteristic analysis, 0.986 ± 0.014, p ≤ 0.001).

Conclusion

Patients with VSS suffer continuously from photophobia at a level similar to chronic migraineurs during attacks. Although migraine and VSS share dysfunctional visual processing, patients with VSS might be more severely affected.

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