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Accelerating Research to Cure Visual Snow Syndrome and give patients their lives back

Occipital cortex and cerebellum gray matter changes in visual snow syndrome

1/4/2022

 
Francesca Puledda, Muriel Bruchhage, Owen O'Daly, Dominic Ffytche, Steven C.R. Williams,  Peter J. Goadsby
First published August 5, 2020, 
DOI: https://doi.org/10.1212/WNL.0000000000010530


Abstract

Objective 

To determine whether regional gray and white matter differences characterize the brain of patients with visual snow syndrome, a newly defined neurologic condition, we used a voxel-based morphometry approach.

Methods
 

In order to investigate whole brain morphology directly, we performed an MRI study on patients with visual snow syndrome (n = 24) and on age- and sex-matched healthy volunteers (n = 24). Voxel-based morphometry was used to determine volumetric differences in patients with visual snow. We further analyzed cerebellar anatomy directly using the high-resolution spatially unbiased atlas template of the cerebellum.

Results
 

Compared to healthy controls, patients with visual snow syndrome had increased gray matter volume in the left primary and secondary visual cortices, the left visual motion area V5, and the left cerebellar crus I/lobule VI area. These anatomical alterations could not be explained by clinical features of the condition.

Conclusion
 

Patients with visual snow syndrome have subtle, significant neuroanatomical differences in key visual and lateral cerebellar areas, which may in part explain the pathophysiologic basis of the disorder.

To access the full article please download the PDF below or download here
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  • Home
  • WHAT IS VISUAL SNOW SYNDROME
    • What is Visual Snow Syndrome >
      • Visual Snow Syndrome Overview
    • Visual Snow Resources
    • Symptoms >
      • Blue Field Entoptic Phenomenon
      • Brain Fog
      • Eye Floaters
      • Glare
      • Nyctalopia
      • Oscillopsia
      • Palinopsia
      • Paresthesia
      • Phosphenes
      • Photophobia
      • Silent Migraine
      • Tinnitus
      • Vertigo
  • HOW TO HELP
    • Donate Once
    • Make a Recurring Donation
    • Corporate Giving & Partners
    • Subscribe
    • Connect with us on Social Media
    • Share your VSS story
    • You Can Fundraise >
      • Volunteer Agreement
    • Events
  • WHAT WE DO
    • About
    • Research & News
    • Research Collaborations
    • Meet our VSS Community
  • Donate